抗泛素抗体Anti-Ubiquitin antibody Ubi-1

产品型号：ab7254

金山科研平台授权一级代理，产品询价请咨询微信：jinshanbio

抗泛素抗体Anti-Ubiquitin antibody [Ubi-1]ELISA, ICC/IF, IHC-Fr, IHC-P, WB，IHC-FoFr，IPReacts with：Human, Mouse, Rat, Chicken, Cow, Dog, Escherichia coli,Horse

金山科研平台授权代理，咨询微信：jinshanbio

抗泛素抗体Anti-Ubiquitin antibody [Ubi-1]

Description Mouse monoclonal [Ubi-1] to UbiquitinHost species MouseSpecificity Ubi-1 was initially screened on ELISA of the immunogen, and subsequently tested on sections of Alzheimer brain. It was one of severalclones which stained neurofibrillary tangles in frozen sectioned material strongly and specifically. Subsequent studies indicated that Ubi-1 is relatively insensitive to formalin fixation and so can be used on mildly fixed histological sections of human brain for studies ofAlzheimer's disease. Ubi-1 also recognizes other ubiquitinated inclusion bodies such as the Lewy bodies of Parkinson's disease andthe Pick bodies in Pick's disease. This antibody recognizes polyubiquitin chains much more strongly than monoubiquitinated moleculesor free ubiquitin. Specifically recognizes ubiquitinated cytoplasmic inclusion bodies.Tested applications IHC-P, WB, ELISA, ICC/IF, IHC-FrCross reactivity Reacts withMouse, Chicken, Cow, Human, Arabidopsis thaliana, Caenorhabditis elegans, Fruit fly （Drosophila melanogaster）Immunogen Full length native protein （purified） conjugated to KLH by a Glutaraldehyde linker.TargetRelevance Ubiquitin is a highly conserved protein of about 8.5 kDa molecular weight, which has an ATP dependent role in the targeting of proteinsfor proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C terminus of ubiquitin,and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly, ubiquitin also becomes covalentlybonded to many types of pathological inclusions, which appear to be resistant to normal degradation. Therefore, ubiquitin antibodiesare very useful for studies of these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic ofAlzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease are all heavily ubiquitinatedand can be readily visualized with ubiquitin antibodies.Cellular localization Cell Membrane, Cytoplasmic and NuclearAlternative names FLJ25987 antibodyMGC8385 antibodyPolyubiquitin B antibodyRPS 27A antibodyRPS27A antibodyUBA 52 antibodyUBA 80 antibodyUBA52 antibodyUBA80 antibodyUBB antibodyUBC antibodyUBCEP 1 antibodyUBCEP 2 antibodyUBCEP1 antibodyUBCEP2 antibodyUbiquitin antibodyubiquitin B antibodyPropertiesForm LiquidStorage instructions Store at +4°C short term （1-2 weeks）. Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

抗泛素抗体Anti-Ubiquitin antibody [Ubi-1]反应性有其他种属的：人，小鼠，大鼠等等

金山科研平台代理abcam产品，咨询抗泛素抗体Anti-Ubiquitin antibody [Ubi-1]详细产品信息